Processed food plastics linked to elevated BP in children: study

plastics-harmful

Plastic additives known as phthalates (pronounced “thal-ates”) are odourless, colourless and just about everywhere: They turn up in flooring, plastic cups, beach balls, plastic wrap, intravenous tubing and – according to the Centers for Disease Control and Prevention – the bodies of most Americans. Once perceived as harmless, phthalates have come under increasing scrutiny. A growing collection of evidence suggests dietary exposure to phthalates (which can leech from packaging and mix with food) may cause significant metabolic and hormonal abnormalities, especially during early development.

Now, new research published in the Journal of Pediatrics suggests that certain types of phthalates could pose another risk to children: compromised heart health. Drawing on data from a nationally representative survey of nearly 3,000 children and teens, researchers at New York University Langone Medical Center (USA), in collaboration with researchers at the University of Washington and Penn State University School of Medicine (USA), have documented for the first time a connection between dietary exposure to DEHP (di-2-ethyhexylphthalate), a common class of phthalate widely used in industrial food production, and elevated systolic blood pressure (BP), a measure of pressure in the arteries when the heart contracts.

“Phthalates can inhibit the function of cardiac cells and cause oxidative stress that compromises the health of arteries. But no one has explored the relationship between phthalate exposure and heart health in children” says lead author Leonardo Trasande, MD, MPP, associate professor of pediatrics, environmental medicine and population health at NYU Langone Medical Center. “We wanted to examine the link between phthalates and childhood blood pressure in particular given the increase in elevated blood pressure in children and the increasing evidence implicating exposure to environmental exposures in early development of disease.”

Hypertension is clinically defined as a systolic BP reading above 140 mmHg. It is most common in people over 50 years old, although the condition is becoming increasingly prevalent among children owing to the global obesity epidemic. Recent national surveys indicate that 14% of American adolescents now have pre-hypertension or hypertension. “Obesity is driving the trend but our findings suggest that environmental factors may also be a part of the problem,” says Dr. Trasande. “This is important because phthalate exposure can be controlled through regulatory and behavioral interventions.”

Researchers from NYU School of Medicine, the University of Washington and Penn State University School of Medicine examined six years of data from a nationally representative survey of the US population administered by the National Centers for Health Statistics of the Centers for Disease Control and Prevention. Phthalates were measured in urine samples using standard analysis techniques. Controlling for a number of potential confounders, including race, socioeconomic status, body mass index, caloric intake and activity levels, the researchers found that every three-fold increase in the level of breakdown products of DEHP in urine correlated with a roughly one-millimeter mercury increase in a child’s BP. “That increment may seem very modest at an individual level, but on a population level such shifts in blood pressure can increase the number of children with elevated blood pressure substantially,” says Dr. Trasande. “Our study underscores the need for policy initiatives that limit exposure to disruptive environmental chemicals, in combination with dietary and behavioral interventions geared toward protecting cardiovascular health.”

This research was made possible through the support of KiDs of NYU Langone, an organization of parents, physicians, and friends that supports children’s health services at New York University Langone Medical Center (USA) through philanthropy, community service, and advocacy.

Read the study in Pediatrics:

Urinary Phthalates Are Associated with Higher Blood Pressure in Childhood

 

 

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